Combining Kratom and Melatonin: A Comprehensive Guide

Combining Kratom and Melatonin: A Comprehensive Guide

What is kratom?

Kratom originates from the leaves of the Mitragyna speciosa tree in Southeast Asia. It’s a tropical evergreen in the Rubiaceae family of flowering plants, which includes coffee. Locals have used this intriguing botanical in traditional cures for centuries.

It’s grown in the humid climes of Thailand, Malaysia, Indonesia, Papua New Guinea, and Myanmar. The indigenous population claims the crushed leaves have several health benefits. Some assert kratom helps with discomfort, cramps, and diarrhea.


kratom leaves


At low doses, it’s said to act as a stimulant. Traditionally, locals chewed the leaves or made tea to improve energy and boost endurance for long days in the fields. At high volumes, it reportedly sedates, and some even use kratom for sleep.

The leaves are crushed and packaged as powder or capsules. Extracts and gummies are also popular methods.

Kratom contains a substance called mitragynine that attaches to opioid receptors in the brain. It provides similar effects to morphine, with some analgesic reactions and euphoria. It may offer an alternative to pharmaceutical opioids.


What is melatonin?

Melatonin is a hormone released by the pineal gland in the middle of your brain in response to darkness. Scientists classify it as an acetamide-class hypnotic. The pea-sized gland increases production in the dark, which induces slumber.

Scientists believe this natural sleep aid helps your circadian rhythms, known colloquially as your internal body clock. When the sun sets, your senses notify the brain, and the pineal gland releases melatonin, regulating your snooze-wake cycle.




Exposure to electrical light from dusk to bedtime suppresses melatonin production and artificially limits the duration. It confuses the body by disguising the natural signal and canceling our physical reaction.

People struggling with their resting patterns or insomnia can take melatonin substitutes to ensure they get enough rest. Producers create them organically or synthetically. Classed as dietary supplements, the FDA doesn’t strictly regulate synthetic versions.

The body uses melatonin to address several problems, like:

  • Jet lag
  • Sleeping issues
  • Immune function
  • Blood pressure
  • Cortisol levels
  • Eye health
  • Seasonal depression
  • Acid reflux

Melatonin also acts as an antioxidant and may significantly improve health in various areas.


The effects of kratom & melatonin interaction

Most enthusiasts use kratom as a stand-alone solution to their issues. Combining it with melatonin is a relatively new technique, and most users add it to enhance the effects of red vein strains. 

Red versions provide relaxation and sedation, leading to calm and sleep. Melatonin works similarly, so the combination seems logically complementary. You ingest a dose of each at the same time.


kratom and melatonin interaction


The interaction between the herbal supplement and natural hormone can be agonistic or antagonistic. The pair can work together or cancel each other out. Chemicals that enhance or promote another reaction are known as pharmacological agonists. 

It’s best to use the same delivery method, so if you’re ingesting kratom in capsules, do likewise with its partner. Melatonin is widely available in tablets.

Some employ a dose of melatonin to take the edge off, perhaps after ingesting white kratom to elevate productivity. Green strains balance inspiration and relaxation. Others, like red Maeng Da, usually lean to sedation, limiting the need for thinking or memory. 

If you take a portion of energetic kratom late in the day, you could temper it with the hormone. 

It involves staggered use, first ingesting the kratom and enjoying the full range of reactions for a few hours. Then, take the melatonin to feel the energy drain and drowsiness descend.

Each kratom strain grows in soil with a unique combination of vitamins and minerals. They create particular combinations of alkaloids with distinct reactions. 

Consider taking a half portion of the plant compound paired with a half dose of melatonin instead. It reduces your kratom intake and delays issues with tolerance and dependency.

Kratom in high doses (especially red strains) produces calming effects and relaxation. Combining it with melatonin may enhance the soothing reactions.

Chemical antagonists pull in opposite directions, effectively canceling each other out. Small doses under five grams offer invigorating results. White strains increase concentration and boost energy, but adding melatonin to the mix might counter that.


What are the possible side effects of taking kratom and melatonin together?

Kratom and melatonin in an agonist combination could produce some side effects, so control consumption carefully. It acts like a double shot and could cause hypersomnolence or excessive sleepiness in inexperienced users.

If they’re antagonists, the melatonin reduces the repercussions of kratom. Taking white strains with the hormone is almost like taking the green vein because it reduces the jittery feeling. Most take the hormone supplement a couple of hours later to wind down.

Taking melatonin supplements could risk allergic reactions. Pregnant or breastfeeding women shouldn’t use either product.


The bottom line

Manage your doses and ensure you buy the highest quality products. Keep your first dose small to discover how your body reacts to this merger. There’s plenty of anecdotal evidence online, but further research is still necessary.

For melatonin supplements, there’s limited information, especially regarding higher doses than what the body typically releases. Short-term use seems safe for most people, but there’s little data for long-term questions.


kratom and melatonin


If you think the combination of kratom and melatonin might be effective, begin cautiously and be strict with your dosage.

Buy the highest quality kratom supplements from Kratom Country. We import from small family farms in Southeast Asia to guarantee the freshest, purest, independently tested products.



Most people know about kratom leaves or the effects of melatonin, but few realize they may be effective in partnership. We answer a few common queries below.


What are the risks associated with the long-term use of kratom and melatonin?

Long-term heavy use of kratom may cause minor side effects, including appetite loss and constipation, insomnia, nausea, or sweating.

Extended use of melatonin ironically produces many of the same issues. Some consumers report constipation, decreased appetite, headache, and drowsiness. There’s limited data as yet on the long-term outcomes of using these products in tandem. 


How do kratom & melatonin affect sleep patterns and REM cycles?

Kratom contains both mitragynine and its metabolite 7-hydroxymitragynine. It acts as a sedative in high doses and could send you to dreamland. Conversely, it produces dynamic responses in lower quantities that eliminate the need for a catnap.

Melatonin is the hormone that tells your body to prepare for your beauty sleep. Electrical lighting impairs production and compromises the effect, resulting in sleep deprivation that can lead to disorders.


How do kratom and melatonin affect cognitive function and memory?

Kratom strains have a broad range of effects that depend on their harvest color and geographical location.

White kratom, for example, provides energetic and focused reactions. Many people seek it out to improve concentration and get motivated. They contend it improves mental clarity and memory.

Melatonin directs cognitive function by releasing the hormone when it gets dark, prompting yawning and feelings of tiredness. It focuses on preparation for the evening and rest.